By Gustavo de los Campos, Daniel Gianola
May 08, 2023
By Marie Reilly
May 04, 2023
This book covers classic epidemiological designs that use a reference/control group, including case-control, case-cohort, nested case-control and variations of these designs, such as stratified and two-stage designs. It presents a unified view of these sampling designs as representations of an ...
By Christos Nakas, Leonidas Bantis, Constantine Gatsonis
April 26, 2023
This book will present a unified and up-to date introduction to ROC methodologies, covering both diagnosis (classification) and prediction. The book will emphasize the practical implementation of these methods using standard statistical software such as R and STATA. Existing books tend to be ...
By Song Zhang, Chul Ahn, Hong Zhu
April 18, 2023
This book begins with an introduction of pragmatic cluster randomized trials (PCTs) and reviews various pragmatic issues that need to be addressed by statisticians at the design stage. It discusses the advantages and disadvantages of each type of PCT, and provides sample size formulas, sensitivity ...
By Jeffrey Wilson, Ding-Geng Chen, Karl E. Peace
March 24, 2023
This book is aimed to compile typical fundamental to advanced statistical methods to be used for health data sciences. This book promotes the applications to health and health-related data. However, the models in this book can be used to analyse any kind of data. The data are analysed with the ...
By Rongling Wu
December 26, 2022
Modern medicine is undergoing a paradigm shift from a "one-size-fits-all" strategy to a more precise patient-customized therapy and medication plan. While the success of precision medicine relies on the level of pharmacogenomic knowledge, dissecting the genetic mechanisms of drug response in a ...
Edited
By Paul Faya, Tony Pourmohamad
December 15, 2022
The subject of this book is applied Bayesian methods for chemistry, manufacturing, and control (CMC) studies in the biopharmaceutical industry. The book has multiple authors from industry and academia, each contributing a case study (chapter). The collection of case studies covers a broad array of ...
Edited
By Bo Yang, Yang Song, Yijie Zhou
December 15, 2022
A disease is defined as rare if the prevalence is fewer than 200,000 in the United States. It is estimated that there are more than 7,000 rare diseases, which collectively affect 30 million Americans or 10% of the US population. This diverse and complex disease area poses challenges for patients, ...
Edited
By Oleksandr Sverdlov, Joris van Dam
December 06, 2022
One of the hallmarks of the 21st century medicine is the emergence of digital therapeutics (DTx)—evidence-based, clinically validated digital technologies to prevent, diagnose, treat, and manage various diseases and medical conditions. DTx solutions have been gaining interest from patients, ...
By Ying Yuan, Ruitao Lin, J. Jack Lee
November 11, 2022
Bayesian adaptive designs provide a critical approach to improve the efficiency and success of drug development that has been embraced by the US Food and Drug Administration (FDA). This is particularly important for early phase trials as they form the basis for the development and success of ...
Edited
By Harry Yang
October 03, 2022
The confluence of big data, artificial intelligence (AI), and machine learning (ML) has led to a paradigm shift in how innovative medicines are developed and healthcare delivered. To fully capitalize on these technological advances, it is essential to systematically harness data from diverse ...
By Catherine Legrand
September 26, 2022
Survival data analysis is a very broad field of statistics, encompassing a large variety of methods used in a wide range of applications, and in particular in medical research. During the last twenty years, several extensions of "classical" survival models have been developed to address particular ...
